The answer is yes and no.
1. It depends on how you have your device set-up. Recalculation on, off or prompted. They can all act slightly (or very) differently.
2. It depends on how you or indeed the device (if you lazily said, “Take me from A to B Mr Nav VI, twisty roads, not motorways”) have created your route. For example, if you have a via or waypoint (ie point(s) you must go through) inside the portion of closed road, the device will keep trying to take you through it. That is where the ‘skip waypoint’ tool comes in. But skip waypoint tool can work in different ways, too.
3. Get to know the detour button. It’s workings are explained in the owner’s handbook. That though can deal with decisions in two different ways, too.
Page 5…..
https://bmw-motorrad.kyiv.ua/files/additions/6066/User Manual Navigator 6.pdf
The best way to get to know it is to ride down a road you know and pretend there is a road block…. Then see how the device works the detour.
All that being said, the way I prefer to do it is have recalculation turned off, then follow any deviation signs and / or navigate myself back onto the route, using the device’s screen as a simple map only.
In short, play around. You can’t break it.
PS If you create your routes in say MyRoute or Google maps, you may well find the route creation algorithm will route you around roads that it knows are closed. Though of course that relies on the maps knowing a road is closed. There is then the Garmin app thing (I forget its name) which I think can pick up data from somewhere. I don’t use it as I find things like that more plague than profit.