I and a friend run 390 Dukes. Great bikes that you can ride hard with less risk of being locked up. The Duke 390 comes with lower gearing and we both find this hard work with too many gear changes and revving its nuts off at higher speed. It comes with a 45 on rear but we are both running 42's. 43 would be even better but you can only buy 43 in Alloy which seem to be made of cheese. The 42 is available in steel and alloy. We both run Steel.
The bike is beautifully light, rides like a 125 with 44bhp, and returns amazing mpg even if you ride it hard. I easi;y get 150 miles a tank and if doing longer runs at say mid 70's on motorway you can get up to 200 miles.
Steve my mate, also on here has done some serious miles on his including trips to the Alps, TT etc.
We both run screens to provide a bit of protection.